Analysts expect earnings of $3.72 per share on $22.87 billion in revenue.
Lilly's revenue slipped last year after it lost patent protection for its all-time best selling drug, the antipsychotic Zyprexa. That exposed the drug to cheaper generic competition.
This year, Lilly loses patent protection for the antidepressant Cymbalta in December and for the insulin Humalog in May.
Cymbalta replaced Zyprexa as Lilly's top seller.
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